Search results for "Differentially expressed mirnas"

showing 3 items of 3 documents

Combined Stress Conditions in Melon Induce Non-additive Effects in the Core miRNA Regulatory Network

2021

Climate change has been associated with a higher incidence of combined adverse environmental conditions that can promote a significant decrease in crop productivity. However, knowledge on how a combination of stresses might affect plant development is still scarce. MicroRNAs (miRNAs) have been proposed as potential targets for improving crop productivity. Here, we have combined deep-sequencing, computational characterization of responsive miRNAs and validation of their regulatory role in a comprehensive analysis of response of melon to several combinations of four stresses (cold, salinity, short day, and infection with a fungus). Twenty-two miRNA families responding to double and/or triple …

MelonBiotic and abiotic stressRNA regulatory networksPlant cultureDifferentially expressed mirnasComputational biologyPlant ScienceBiologyCrop productivitybiotic and abiotic stressSB1-1110crop production and climate changePlant developmentGENETICAMiRNAs and stress response in Cucumis melomiRNAs and stress response in Cucumis melomicroRNACrop production and climate changeRNA regulatory networks; RNA-seq and systems biology; biotic and abiotic stress; crop production and climate change; miRNAs and stress response in Cucumis meloStress conditionsTranscription factorGeneRNA-seq and systems biologyOriginal ResearchFrontiers in Plant Science
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Early detection of lung cancer in exhaled breath condensate using miRNA markers

2015

Background: Lung cancer is the leading cause of death by cancer worldwide. Since 5-year survival rate increases significantly when lung cancer is diagnosed at early stages, the development of accurate non-invasive biomarkers for early lung cancer diagnosis is of utmost importance. Over the last years, several tumour biomarkers based on microRNAs (miRNAs) determined in exhaled breath condensate (EBC) have been evaluated and could be applied to early diagnosis of lung cancer. Rationale: miRNA signatures for surgical specimens of lung cancer have been determined providing a panel of differentially expressed miRNAs that were able to discriminate lung cancer patients from normal subjects. Using …

Oncologymedicine.medical_specialtybusiness.industryCancerEarly detectionDifferentially expressed mirnasrespiratory systemmedicine.diseaserespiratory tract diseasesInternal medicinemicroRNAMedicineExhaled breath condensatebusinessLung cancerSurvival rateCause of death11.1 Lung Cancer
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Exploring the miRNA-mediated response to combined stresses in melon plants

2021

AbstractClimate change has been associated with a higher incidence of combined adverse environmental conditions that can promote a significant decrease in crop productivity. However, knowledge on how a combination of stresses might affect plant development is still scarce. MicroRNAs (miRNAs) have been proposed as potential targets for improving crop-productivity. Here, we have combined deep-sequencing, computational characterization of responsive miRNAs and validation of their regulatory role in a comprehensive analysis of melon’s response to several combinations of four stresses (cold, salinity, short day, and infection with a fungus). Twenty-two miRNA families responding to double and/or …

Plant developmentMelonmicroRNADifferentially expressed mirnasComputational biologyBiologyGeneTranscription factorCrop productivity
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